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Antidepressants No More Effective Than Placebos


A new study published in the Public Library of Science Journal claims that SSRI antidepressants Prozac, Effexor, Paxil, and Serzone are no more effective than placebos, except in the case of those who are "at the upper end of the very severely depressed category."

"Although patients get better when they take antidepressants, they also get better when they take a placebo, and the difference in improvement is not very great," lead researcher Irving Kirsch, a professor of psychology at the University of Hull in Great Britain, said in a prepared statement. "This means that depressed people can improve without chemical treatments," he added.

The researchers got their results by examining unpublished drug trial results done by the drug companies. They got the study results from the FDA through the Freedom of Information Act.

Not surprisingly, the drug companies aren't thrilled with the results of the review. A spokesperson from Prozac manufacturer Eli Lilly said the study "does not take into account that today more than 12,000 patients have participated in Prozac clinical trials and thousands of scientific papers have referenced Prozac, supporting its use in the treatment of depression."

GlaxoSmithKline, makers of Paxil, said, "This analysis has only examined a small subset of the total data available ... and this one study should not be used to cause unnecessary alarm and concern for patients."

Filed under Antidepressants, Effexor, Paxil

Comments (24) | Leave a comment

Script medications especially SSRI and SNRI anti-depressants that re-wire the brain and actually change your core identity - do very destructive things and no one explains that to the patient. They are... Generic Wellbutrin, Paxil,Zoloft,Cymbalta, Effexor, Prozac are a few of the more widely prescribed. Millions take these drugs daily for years.....many end up loosing the feelings of love, compassion, remorse etc. they had for their loved ones....they end up with impulsive behaviors, crave alcohol and drink heavily ...... causing unnecessary turmoil in a once loving family and then divorce just because people aren't told nor understand the damage these widely prescribe meds cause. They act as amphetamines in the system and are very hard to come off of without professional help. It's the most hidden dependency out ther today.

O'h, the depression is gone but so is everything else once normal to that person!

Posted by Paul on September 7, 2008 5:09 PM | Permalink | Reply

what is placebos

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A spokesperson from Prozac manufacturer Eli Lilly said the study "does not take into account that today more than 12,000 patients have participated in Prozac clinical trials and thousands of scientific papers have referenced Prozac, supporting its use in the treatment of depression."

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Placebos are more effective than all the depressants.

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Anti-depressants are unfortunately a source of drug abuse nowadays. People who take them in huge doses above the prescribed frequency want to take the easy and quick fix to curbing depression.

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